The ingredients contained in the SkinMason IO Supplement and their support of skin health have much scientific backing. A selection of sources is included below.

Arjinpathana N, Asawanonda P.

“Oral glutathione as a skin-whitening agent: A randomized, double-blind, placebo-controlled study.”

Journal of Dermatological Treatment. 2012 Apr;23(2):97–102.

Summary: Oral glutathione supplementation significantly reduced melanin indices in treated subjects, supporting claims related to skin brightening and pigmentation control.

Weschawalit S, Thongthip S, Phutrakool P, Asawanonda P.

“Glutathione and its antiaging and antimelanogenic effects.”

Clinical, Cosmetic and Investigational Dermatology. 2017;10:147–153.

Summary: Reviews glutathione’s antioxidant, antimelanogenic, and anti-aging effects, supporting claims around oxidative stress reduction and skin tone improvement.

Townsend DM, Tew KD, Tapiero H.

“The importance of glutathione in human disease.”

Biomedicine & Pharmacotherapy. 2003 May;57(3-4):145–155.

Summary: Establishes glutathione as a central endogenous antioxidant involved in detoxification and cellular defense systems.

Pullar JM, Carr AC, Vissers MCM.

“The roles of vitamin C in skin health.”

Nutrients. 2017 Aug;9(8):866.

Summary: Comprehensive review showing vitamin C’s role in collagen synthesis, antioxidant defense, wound healing, and pigmentation regulation.

Cosgrove MC, Franco OH, Granger SP, Murray PG, Mayes AE, Robinson SM.

“Dietary nutrient intakes and skin-aging appearance among middle-aged American women.”

American Journal of Clinical Nutrition. 2007 Oct;86(4):1225–1231.

Summary: Higher vitamin C and linoleic acid intake correlated with reduced skin wrinkling and improved appearance, supporting nutrition-based skin aging claims.

Chen AC, Martin AJ, Choy B, Fernández-Peñas P, Dalziell RA, McKenzie CA, et al.

“A Phase 3 randomized trial of nicotinamide for skin-cancer chemoprevention.”

New England Journal of Medicine. 2015 Oct 22;373(17):1618–1626.

Summary: Nicotinamide reduced rates of nonmelanoma skin cancers and actinic keratoses, supporting claims related to photoprotection and skin resilience.

Niren NM, Torok HM.

“The Nicomide Improvement in Clinical Outcomes Study (NICOS): results of an 8-week trial.”

Cutis. 2006 Jan;77(1 Suppl):17–28.

Summary: Oral nicotinamide-containing supplementation improved inflammatory acne outcomes, supporting claims around skin clarity and barrier support.

Dreno B, Moyse D, Alirezai M, Amblard P, Auffret N, Beylot C, et al.

“Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate versus minocycline hydrochloride in the treatment of inflammatory acne vulgaris.”

Dermatology. 2001;203(2):135–140.

Summary: Zinc gluconate demonstrated efficacy in inflammatory acne management, supporting anti-inflammatory and skin-clearing claims.

Ozuguz P, Kacar SD, Ekiz O, Takci Z, Basat O, Karaca S.

“Evaluation of serum vitamins A and E and zinc levels according to acne severity.”

Cutaneous and Ocular Toxicology. 2014;33(2):99–102.

Summary: Lower antioxidant vitamin and zinc levels were associated with increased acne severity, supporting nutrient-skin health relationships.

Aust O, Stahl W, Sies H, Tronnier H, Heinrich U.

“Supplementation with tomato-based products increases lycopene, phytofluene and phytoene levels in human serum and protects against UV-light-induced erythema.”

International Journal for Vitamin and Nutrition Research. 2005 Jan;75(1):54–60.

Summary: Lycopene-rich supplementation improved serum carotenoid levels and reduced UV-induced erythema, supporting internal photoprotection claims.

Rizwan M, Rodriguez-Blanco I, Harbottle A, Birch-Machin MA, Watson REB, Rhodes LE.

“Tomato paste rich in lycopene protects against cutaneous photodamage in humans in vivo.”

British Journal of Dermatology. 2011 Jan;164(1):154–162.

Summary: Lycopene supplementation reduced markers of UV-mediated photodamage and collagen degradation in human skin.

Stahl W, Sies H.

“Carotenoids and flavonoids contribute to nutritional protection against skin damage from sunlight.”

Molecular Biotechnology. 2007 Mar;37(1):26–30.

Summary: Demonstrates how dietary antioxidants such as carotenoids contribute to protection against photoaging and oxidative skin stress.

Abbasi F, et al.

“A systematic review and meta-analysis of clinical trials on the effect of glutamine supplementation on intestinal permeability.”

Amino Acids.2024 Oct 13;56(1):60.

Summary: Glutamine supplementation significantly reduced intestinal permeability in clinical studies, supporting gut barrier integrity and gut-skin axis claims

Wang J, et al.

“Glutamine Peptides: Preparation, Analysis, Applications.”

Nutrients. 2025.

Summary: Reviews evidence that glutamine supports intestinal tight junctions, inflammatory regulation, and microbiome balance, supporting systemic inflammatory and barrier claims.

Trompette A, et al.

“Gut-derived short-chain fatty acids modulate skin barrier function.”

Mucosal Immunology. 2022.

Summary: Demonstrates that gut-mediated barrier signaling can directly improve epidermal integrity and reduce inflammatory sensitization, strengthening the mechanistic rationale behind gut-support ingredients like glutamine.

Muizzuddin N, Maher W, Sullivan M, Schnittger S, Mammone T.

“Physiological effect of a probiotic on skin.”

Journal of Cosmetic Science. 2012.

Summary: Lactobacillus plantarum supplementation improved acne-associated erythema and reduced lesion counts, supporting anti-inflammatory and skin barrier claims.

Liang L, et al.

“Lactobacillus plantarum MH-301 as an effective adjuvant to acne treatment.”

Frontiers in Medicine. 2024.

Summary: L. plantarum supplementation improved acne outcomes and supported microbiome-mediated inflammatory regulation.

Sutema IAMP, et al.

“Efficacy of Probiotic Supplements and Topical Applications in the Treatment of Acne.”

Journal of Experimental Pharmacology. 2025.

Summary: Reviews evidence showing Lactobacillus plantarum CJLP55 reduced acne lesions and improved skin hydration and lipid barrier integrity.

Nestor MS, Berman B, Swenson N.

“Safety and efficacy of oral Polypodium leucotomos extract in healthy adult subjects.”

Journal of Clinical and Aesthetic Dermatology. 2015 Feb;8(2):19–23.

Summary: Demonstrated that oral Polypodium leucotomos was safe and provided systemic photoprotective benefits against UV-induced skin damage.

Middelkamp-Hup MA, Pathak MA, Parrado C, García-Caballero T, Rius-Díaz F, Fitzpatrick TB, González S.

“Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin.”

Journal of the American Academy of Dermatology. 2004 Jun;51(6):910–918.

Summary: Oral supplementation reduced UV-mediated skin injury, supporting claims regarding photoprotection and oxidative defense.

González S, Gilaberte Y, Philips N, Juarranz A.

“Current trends in photoprotection — Polypodium leucotomos as an oral photoprotective agent.”

Photochemical & Photobiological Sciences. 2011;10(2):251–259 .

Summary: Reviews mechanistic evidence for Polypodium leucotomos in reducing UV-induced inflammation, ROS formation, and photoaging.

Fabbrocini G, Bertona M, Picazo Ó, Pareja-Galeano H, Monfrecola G, Emanuele E.

“Supplementation with Lactobacillus rhamnosus SP1 normalises skin expression of insulin signaling-associated genes in adult acne.”

Beneficial Microbes. 2016 Aug;7(4):625–630.

Summary: Probiotic supplementation improved acne-associated molecular signaling, supporting gut-skin axis and inflammatory regulation claims.

Sánchez-Pellicer P, Navarro-López V, Ramón-Vidal D, et al.

“Oral probiotic supplementation in acne vulgaris: a randomized controlled trial.”

Acta Dermato-Venereologica. 2024;104:adv33206.

Summary: Oral probiotics improved acne severity and inflammatory outcomes, supporting microbiome-targeted interventions for skin health.

Guéniche A, Benyacoub J, Philippe D, Bastien P, Kusy N, Breton L, Blum S, Castiel-Higounenc I.

“Lactobacillus paracasei NCC2461 reduces skin sensitivity and improves skin barrier function.”

Beneficial Microbes. 2014 Jun;5(2):137–145.

Summary: Demonstrated improved skin barrier integrity and reduced sensitivity with probiotic supplementation.

Hadi A, Pourmasoumi M, Ghavami A, et al.

“Bifidobacterium longum and galacto-oligosaccharide improve skin barrier dysfunction and atopic dermatitis-like symptoms.”

Allergy Asthma & Immunology Research. 2022;14(6):660–673.

Summary: B. longum supplementation improved skin barrier function and reduced inflammatory skin symptoms, supporting microbiome and barrier integrity claims.

Guéniche A, et al.

“Lactobacillus paracasei NCC2461 reduces skin sensitivity and improves skin barrier function.”

Beneficial Microbes. 2014 Jun;5(2):137–145.

Summary: Demonstrates oral probiotic modulation of skin sensitivity and barrier function, strengthening the broader rationale for microbiome-mediated skin resilience.

Salem I, Ramser A, Isham N, Ghannoum MA.

“The gut microbiome as a major regulator of the gut-skin axis.”

Frontiers in Microbiology. 2018 Jul;9:1459 .

Summary: Reviews mechanistic links between gut microbial composition, systemic inflammation, and dermatologic outcomes.

O’Neill CA, Monteleone G, McLaughlin JT, Paus R.

“The gut-skin axis in health and disease: a paradigm with therapeutic implications.”

BioEssays. 2016 Nov;38(11):1167–1176.

Summary: Establishes the gut-skin axis as a clinically meaningful pathway influencing immunity, inflammation, and skin disease.

Zhang J, Yao Z.

“Immune cell trafficking: a novel perspective on the gut-skin axis.”

Inflammation and Regeneration. 2024;44:21.

Summary: Explores how immune cell migration links gut dysbiosis with inflammatory skin conditions.

Woo YR, Kim HS.

“Interaction between the microbiota and the skin barrier in aging skin: a comprehensive review.”

Frontiers in Physiology. 2024;15:1322205.

Summary: Reviews microbiome-mediated mechanisms contributing to skin aging and barrier dysfunction.

Hong JY, Kwon D, Park KY.

“Microbiome-based interventions for skin aging and barrier function: a comprehensive review.”

Annals of Dermatology. 2025;37(5):259–268.

Summary: Supports the emerging role of microbiome-directed therapies in improving skin aging, hydration, and barrier integrity.

Tseng CH, Wu CY.

“From dysbiosis to longevity: a narrative review into the gut microbiome’s impact on aging.”

Journal of Biomedical Science. 2025;32:93.

Summary: Connects microbiome balance with systemic aging pathways, supporting longevity-oriented wellness positioning.